Traditional open surgical approaches for hypopharyngeal carcinomas carry a great risk of developing treatment-related morbidity.Transoral robotic surgery (TORS) is an established treatment modality for head and neck cancer and can minimise this morbidity.Owing to the access and improved flexibility of the robotic system, hypopharyngeal tumours can
IDH1 Promotes Foam Cell Formation by Aggravating Macrophage Ferroptosis
A distinctive feature of ferroptosis is intracellular iron accumulation and the impairment of antioxidant capacity, resulting in a lethal accumulation of lipid peroxides leading to cell death.This study was conducted to determine whether inhibiting isocitrate dehydrogenase 1 (IDH1) may help to prevent foam cell formation by reducing oxidized low-de
Topological Corner States in Non-Unitary Coinless Discrete-Time Quantum Walks
The discrete-time quantum walk provides a versatile platform for exploring abundant topological phenomena due to its intrinsic spin-orbit coupling.In this work, we study the non-Hermitian second-order topology in a two-dimensional non-unitary coinless discrete-time quantum walk, which is realizable in the three-dimensional photonic waveguides.By ad
The Role of Plzf in Spermatogonial Stem Cell Maintenance and Differentiation: Mapping the Transcriptional Dynamics and Key Interactions
Spermatogonial stem cells (SSCs) sustain and modulate spermatogenesis through intricate signaling pathways and transcription factors.Promyelocytic leukemia zinc-finger (Plzf, also known as Zbtb16) has been identified as a critical transcription factor influencing various signaling and differentiation pathways.Plzf plays a pivotal role in regulating